Noted Publications:

• Zong WX, Edelstein LC, Chen C, Bash J, and Gelinas C. 1999. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kB that blocks TNFa-induced apoptosis. Genes Dev 13, 382-387 .
• Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, and Thompson CB. 2000. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6, 1389-1399.
• Wei MC, Zong WX (co-first author), Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, and Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730.
• Zong WX, Lindsten T, Ross AJ, MacGregor GR, and Thompson CB. 2001. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15, 1481-1486
• McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N, and Chandel NS. 2002. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol 22, 94-104.
• Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, and Davis RJ. 2002. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 22, 4929-4942.
• Rathmell JC, Lindsten T, Zong WX, Cinalli RM, and Thompson CB. 2002. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 3, 932-939.
• Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, and Thompson CB. 2003. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162, 59-69.
• Zong WX, Ditsworth D, Bauer DE, Wang ZQ, and Thompson CB. 2004. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18: 1272-1282.
• Zong WX and Thompson CB. 2006. Necrotic death as a cell fate. Genes Dev. 1:20(1):1-15.
• Muthumani K, Choo AY, Zong WX, Madesh M, Hwang DS, Premkumar A, Thieu KP, Emmanuel J, Kumar S, Thompson CB, Weiner DB. 2006. The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol. Feb;8(2):170-9. Epub Jan 22. Erratum in: Nat Cell Biol. Mar; 8(3):299.
• Ricci MS, Zong WX. 2006. Chemotherapeutic approaches for targeting cell death pathways. Oncologist. Apr;11(4):342-57.
• Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen L, and Luo ZQ. 2007. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. PNAS 104:5121-5126.
• Ditsworth D, Zong WX, and Thompson CB. 2007. Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus.  J Biol Chem 282:17845-17854.
• Simmons MJ, Fan G, Zong WX, Degenhardt K, White E, and Gélinas C.  2007. Bfl-1/A1 selectively interacts with endogenous tBid and Bak but not Bax to suppress apoptosis.  Oncogene. In press.
• Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z, and Zong WX. 2007. Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress.  Cell Death Differ. In press.