Genome structure and translational control.

• Kitamura, N., Semler, B. L., Rothberg, P. G., Larsen, G. R., Adler, C. J., Dorner, A. J., Emini, E. A., Hanecak, R., Lee, J. J., van der Werf, S., Anderson, C. W. and Wimmer, E. Primary structure, gene organization and polypeptide expression of poliovirus RNA. Nature 29l:547-553 (l98l).
• van der Werf, S. Bradley, J. Wimmer, E., Studier, F. W., and Dunn, J. J. Synthesis of Infectious Poliovirus RNA by Purified T7 RNA Polymerase. Proc. Natl. Acad. Sci. USA, 83:2330-2334 (1986).
• Jang, S. K., Kräusslich, H.-G., Nicklin, M. J. H., Duke, G. M., Palmenberg, A. C. and Wimmer, E. Evidence in Vitro for Internal Entry by the Translational Machinery in the 5' Non-Translated Region of Encephalomyocarditis Virus RNA. J. Virol. 62:2636-2643 (1988).
  
• Paul, A.V., v. Boom, J., Filippov, D., and Wimmer, E. Protein-primed RNA Synthesis by Purified Poliovirus RNA Polymerase. Nature 393:280-284 (1998)
• Paul, A.V., Rieder, E., Kim, D.W., van Boom, J.H., and Wimmer E. Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg. J. Virol. 74:10359-10370 (2000)
• Paul, A.V. Possible unifying mechanism of picornavirus genome replication. In "Molecular Biology of Picornaviruses", B.S. Semler and E. Wimmer, eds. ASM Press 2002, pp 227-246.
• Duggal, R., Cuconati, A., Gromeier, M., and Wimmer E. Genetic Recombination of Poliovirus in a Cell-Free System. Proc. Natl. Acad. Sci. (USA) 94: 13786-13791 (1997).
• Jiang, P., Faase, J. A., Toyoda, H., Paul, A., Wimmer, E., and Gorbalenya, A. E. Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication. Proc. Natal. Acad. Sci. 104:9457-9462 (2007).olla, A., Paul, A.V., and Wimmer, E. Cell-free, de novo synthesis of poliovirus. Science 254:1647-1651 (1991).

Poliovirus receptor and pathogenesis.

• Mendelsohn, C.L., Wimmer, E., and Racaniello, V.R. Cellular Receptor for Poliovirus: Molecular Cloning, Nucleotide Sequence, and Expression of a New Member of the Immunoglobulin Super-family. Cell, 56, 855-865 (1989).
• Gromeier, M., Lachmann, S., Rosenfeld, M. R., Gutin, P. H., and Wimmer, E. Intergeneric Poliovirus Recombinants for the Treatment of Malignant Glioma. Proc. Natl. Acad. Sci. (USA) 97:6803-6808 (2000).
• Zhang, P., Mueller, S., Morais, M. C., Bator, C. M., Bowman, V. D., Hafenstein, S., Wimmer, E., and Rossman, M. G. 2008. Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses. Proc. Natl. Acad. Sci. USA 105:18284-18289.
• Toyoda, H., Yin, J., Mueller, S., Wimmer, E., and Cello, J. 2007. Oncolytic treatment and cure of neuroblastoma by a novel attenuated poliovirus in a novel poliovirus-susceptible animal model. Cancer Res. 67:2857-2864.

De novo synthesis of poliovirus and synthetic biology.

• Molla, A., Paul, A. V., and Wimmer, E. 1991. Cell-free de novo synthesis of poliovirus. Science 254:1647-1651.
• Cello, J., Paul, A., and Wimmer, E. Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template. Science 297:1016-1018 (2002).
• Mueller, S., Papamichail, D., Coleman, J. R., Skiena, S., and Wimmer, E. 2006. Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivity. J. Virol. 80:9687-9696.
• Coleman, J. R., Papamichail, D., Skiena, D., Futcher, B., Wimmer, E., and Mueller, S. 2008. Virus attenuation by genome-scale changes in codon pair bias. Science 320:1784-1787.