Noted Publications:

• Krug LT, Collins CM, Gargano LM, Speck SH. NF-kappaB p50 plays distinct roles in the establishment and control of murine gammaherpesvirus 68 latency. J Virol. 2009 May;83(10):4732-48.
• Forrest, JC*, Krug, LT*, SH Speck. (*shared first authorship) 2008. Murine gammaherpesvirus 68 infection of mice: a small animal model for characterizing basic aspects of gamma-herpesvirus pathogenesis. In: Dammania, B., Pipas, J. (Eds.), DNA Tumor Viruses. Springer, New York. In press.
• Evans, A.G., Moser, J.M., Krug, L.T., Pozharskaya, V., Mora, A.L., Speck, S.H. (2008) A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. J Exp Med. 17;205(3):669-84.
• Krug, LT, C Teo, K Tanaka-Taya, and N Inoue. 2007. Newly identified human herpesviruses: HHV-6, -7, and -8. In: Fong, I.W., Alibek, K. (Eds.), New and Evolving Infections of the 21st Century. Springer, New York, pp. 197-242.
• Krug, L.T., Moser, J.M., Dickerson, S.M., Speck, S.H. (2007) Inhibition of NF-kappaB activation in vivo impairs establishment of gammaherpesvirus latency. PLoS Pathog. 3(1):e11.
• Moser, J.M., Farrell, M.L., Krug, L.T., Upton, J.W., Speck, S.H. (2006) A gammaherpesvirus 68 gene 50 null mutant establishes long-term latency in the lung but fails to vaccinate against a wild-type virus challenge. J Virol. 80(3):1592-8.
• Klass, C.M., Krug, L.T., Pozharskaya, V.P., Offermann, M.K. (2005) The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production. Blood. 105(10):4028-34.
• Elliott, J., Goodhew, E.B., Krug, L.T., Shakhnovsky, N., Yoo, L., Speck, S.H. (2004) Variable methylation of the Epstein-Barr virus Wp EBNA gene promoter in B-lymphoblastoid cell lines. J Virol. 78(24):14062-5.
• Krug, L.T., Pozharskaya, V.P., Yu, Y., Inoue, N., Offermann, M.K. (2004) Inhibition of infection and replication of human herpesvirus 8 in microvascular endothelial cells by alpha interferon and phosphonoformic Acid. J Virol. 78(15):8359-71.
• Pozharskaya, V.P., Weakland, L.L., Zimring, J.C., Krug, L.T., Unger, E.R., Neisch, A., Joshi, H., Inoue, N., Offermann, M.K.(2004) Short duration of elevated vIRF-1 expression during lytic replication of human herpesvirus 8 limits its ability to block antiviral responses induced by alpha interferon in BCBL-1 cells. J Virol. 78(12):6621-35.
• Krug, L.T., Inoue, N., Pellett, P.E. (2001) Differences in DNA binding specificity among Roseolovirus origin binding proteins. Virology. 288(1):145-53.
• Krug, L.T., Inoue, N., Pellett, P.E. (2001) Sequence requirements for interaction of human herpesvirus 7 origin binding protein with the origin of lytic replication. J Virol. 75(8):3925-36.
• Rapp, J.C., Krug, L.T., Inoue, N., Dambaugh, T.R., Pellett, P.E. (2000) U94, the human herpesvirus 6 homolog of the parvovirus nonstructural gene, is highly conserved among isolates and is expressed at low mRNA levels as a spliced transcript. Virology. 268(2):504-16.