Noted Publications:

• Agazie Y., Ischenko I., and Hayman M.J. Concomitant activation of multiple signaling pathways is essential for transformation by the v-Sea tyrosine kinase oncogene. Oncogene, 21: 697-707. (2002).
• Agazie Y. M., and Hayman M.J. Development of an Efficient "Substrate-trapping" Mutant of Src Homology Phosphotyrosine Phosphatase 2 and Identification of the Epidermal Growth Factor Receptor, Gab1, and Three Other Proteins as Target Substrates. J. Biol. Chem. 278: 13952-13958 (2003)
• Ischenko I., Petrenko O, Gu H., and Hayman M. J. The scaffolding protein Gab2 mediates fibroblast transformation by the Sea tyrosine kinase. Oncogene 22:6311-6318 (2003).
• Agazie Y.M., Movilla N., Ischenko I. and Hayman, M.J. The Phosphotyrosine Phosphatase SHP2 is a Critical Mediator of Transformation Induced by the Oncogenic Fibroblast Growth Factor Receptor 3 . Oncogene 22, 6909-6918 (2003)
• Ueki N. and Hayman M.J. Signal-dependent N-CoR Requirement for Repression by the Ski oncoprotein. J. Biol. Chem. 278: 24858-24864 (2003)
• Ueki N., and Hayman M.J. Direct interaction of Ski with either Smad3 or Smad4 is necessary and sufficient for Ski-mediated repression of TGF- signaling. J Biol Chem. 278:32489-32492. (2003)
• Agazie Y.M. and Hayman M.J. Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol. Cell. Biol. 23: 7875-7886.(2003)
• Leong G. M., Subramaniam N., Issa L. L., Barry J. B., Kino T., Driggers P. H., Hayman M. J., Eisman J. A., Gardiner E. M. Ski-interacting protein (SKIP), a Bifunctional Nuclear Receptor Coregulator that interacts with N-CoR/SMRT and p300. B.B.R.C. 315 1070-1076 (2004).
• Figueroa J. D. and Hayman. M. J. Differential effects of the Ski-interacting Protein (SKIP) on differentiation induced by Transforming Growth Factor-Beta-1 and Bone Morphogenetic Protein-2 in C2C12 cells. Exp Cell Research 296:163-72. (2004)
• Figueroa J. D. and Hayman M. J. The human Ski-interacting protein (SKIP) functionally substitutes for the yeast PRP45 gene. B.B.R.C. 319:1105-1109. (2004)
• Ueki. N., Zhang L., and Hayman M.J. Ski negatively regulates erythroid differentiation through its interaction with GATA-1. Mol Cell Biol. 24:10118-25. (2004)
• Yokohama N., Ischenko I., Hayman M.J., and Miller W.T. The C-terminus of the RON tyrosine kinase plays and autoinhibitory role. J. Biol. Chem. 280:8893-900. (2005)
• McLaughlin S., Smith S.O., Hayman M.J., and Murray D. An Electrostatic Engine Model for Autoinhibition and Activation of the Epidermal Growth Factor Receptor (EGFR/ErbB) Family. J. Gen. Physiol 126:41-53. (2005)
• Marcelain K., and Hayman M.J. The Ski oncoprotein is upregulated and localized at the centrosomes and mitotic spindle during mitosis. Oncogene 24:4321-9. (2005)
• Merritt R, Hayman MJ, Agazie YM. Mutation of Thr466 in SHP2 abolishes its phosphatase activity, but provides a new substrate-trapping mutant.
  Biochim Biophys Acta. 1763(1):45-56. (2006)
• Ritter M, Kattmann D, Teichler S, Hartmann O, Samuelsson MK, Burchert A, Bach JP, Kim TD, Berwanger B, Thiede C, Jager R, Ehninger G, Schafer H, Ueki N, Hayman MJ, Eilers M, Neubauer A. Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia. Leukemia. 20(3):437-43. (2006)