The major focus of our research is on the pathogenesis of spirochetal infections and their host responses, particularly in the developmental bactericidal antibodies that work independently of the complement system. These antibodies appear to be more common than previously thought, and may be a very important part of the host repertoire against bacteria.

We are also interested in the interaction of spirochetal outer surface components with host proteases to enhance invasiveness, and to understand how this borrowed proteolytic activity enhances penetration of these organisms into the central nervous system.

Come visit us at the Center for Infectious Diseases